Micronutrient Deficiency and Treatment Adherence in a Randomized Controlled Trial of Micronutrient Supplementation in ART-Naive Persons with HIV

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INTRODUCTION: The MAINTAIN study is an on-going RCT comparing high-dose micronutrient and anti-oxidant supplementation versus recommended daily allowance (RDA) vitamins in slowing HIV immune deficiency progression in ART-naïve people with HIV infection. OBJECTIVE: We planned analysis of the first 127 participants to determine the baseline prevalence of serum micronutrient deficiencies and correlates, as well as tolerance and adherence to study interventions. METHODS: Participants receive eight capsules twice daily of 1) high-dose or 2) RDA supplements for two years and are followed-up quarterly for measures of immune deficiency progression, safety and tolerability. Regression analysis was used to identify correlates of micronutrient levels at baseline. Adherence was measured by residual pill count, self-report using the General Treatment Scale (GTS) and short-term recall HIV Adherence Treatment Scale (HATS). RESULTS: Prior micronutrient supplementation (within 30 days) was 27% at screening and 10% of study population, and was not correlated with baseline micronutrient levels. Low levels were frequent for carotene (24%
Title of abstract: 
Micronutrient Deficiency and Treatment Adherence in a Randomized Controlled Trial of Micronutrient Supplementation in ART-Naive Persons with HIV
Author: 
Balfour L, Spaans JN, Fergusson DA, Huff H, Mills EJ, la Porte CJ, Walmsley S, Singhal N, Rosenes R, Tremblay N, Gill MJ, Loemba H, Brian Conway B, Rachlis A, Ralph E, Loutfy M, Mallick R, Moorhouse R, Cameron DM
Affiliations: 
Canadian College of Naturopathic Medicine, University of Ottawa, Ottawa Hospital Research Institute, University of British Columbia, University of Calgary
Citedate: 
Tuesday, December 31, 2013 - 19:00
Citation: 
PLoS One. January 21, 2014. DOI: 10.1371/journal.pone.0085607
Taxonomy: 

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