Melatonin as adjuvant cancer care with and without chemotherapy: meta-analysis

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BACKGROUND: Melatonin (MLT) is known to possess potent antioxidant, antiproliferative, immune-modulating, and hormone-modulating properties. Clinical evidence suggests that MLT may have a possible role in the treatment of cancer. The authors systematically reviewed the effects of MLT in conjunction with chemotherapy, radiotherapy, supportive care, and palliative care on 1-year survival, complete response, partial response, stable disease, and chemotherapy-associated toxicities. METHODS: The authors searched 7 databases: MEDLINE (1966-February 2010), AMED (1985-February 2010), Alt HealthWatch (1995-February 2010), CINAHL (1982-February 2010), Nursing and Allied Health Collection: Basic (1985-February 2010), the Cochrane Database (2009), and the Chinese database CNKI (1979-February 2010). They included all trials that randomized patients to treatment, including MLT or a similar control group without MLT. RESULTS: The authors included data from 21 clinical trials, all of which dealt with solid tumors. The pooled relative risk (RR) for 1-year mortality was 0.63 (95% confidence interval [CI] = 0.53-0.74; P
Title of abstract: 
Melatonin as adjuvant cancer care with and without chemotherapy: A systematic review and meta-analysis of randomized trials
Seely D, Wu P, Fritz H, Kennedy DA, Tsui T, Seely AJ, Mills E
The Canadian College of Naturopathic Medicine, Toronto, ON, Canada; Ottawa Integrative Cancer Center; Ottawa Hospital Research Institute, Ottawa, Canada
Friday, December 31, 2010 - 19:00
Integr Cancer Ther. 2012 Dec;11(4):293-303.

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