Cancer https://ccnm.edu/ en Intravenous Vitamin C in Cancer Care: Evidence Review and Practical Guidance for Integrative Oncology Practitioners https://ccnm.edu/research-abstracts/intravenous-vitamin-c-cancer-care-evidence-review-and-practical-guidance <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--research-abstract.html.twig x field--node--title.html.twig * field--node--research-abstract.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <span>Intravenous Vitamin C in Cancer Care: Evidence Review and Practical Guidance for Integrative Oncology Practitioners</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--uid--research-abstract.html.twig x field--node--uid.html.twig * field--node--research-abstract.html.twig * field--uid.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--uid.html.twig' --> <span> <!-- THEME DEBUG --> <!-- THEME HOOK: 'username' --> <!-- BEGIN OUTPUT from 'core/modules/user/templates/username.html.twig' --> <span lang="" about="/user-profile/sana" typeof="schema:Person" property="schema:name" datatype="">sana</span> <!-- END OUTPUT from 'core/modules/user/templates/username.html.twig' --> </span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--uid.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--created--research-abstract.html.twig x field--node--created.html.twig * field--node--research-abstract.html.twig * field--created.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--created.html.twig' --> <span>Wed, 03/27/2024 - 11:25</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--created.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'links__node' --> <!-- FILE NAME SUGGESTIONS: * links--node.html.twig x links.html.twig --> <!-- BEGIN OUTPUT from 'themes/bootstrap/templates/system/links.html.twig' --> <!-- END OUTPUT from 'themes/bootstrap/templates/system/links.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--body--research-abstract.html.twig * field--node--body.html.twig * field--node--research-abstract.html.twig * field--body.html.twig * field--text-with-summary.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><h3>Abstract</h3> <p>Intravenous vitamin C (IVC) is a common therapy used by naturopathic doctors and other licensed integrative practitioners. With several proposed mechanisms of action related to cancer care, it is often used in integrative oncology settings. Despite its common use, there are no published evidence-based resources on the efficacy, safety, and procedural considerations for the use of IVC in practice. The objectives of this review are to summarize the evidence on high-dose IVC in supportive cancer care and to provide a resource of practical clinical guidance for IVC application. In cancer care, IVC is most commonly used at doses high enough to achieve a potential cancer cell cytotoxicity. This review focuses on IVC at doses of ≥15 g which we have defined as high-dose. To date, there are 23 published clinical trials evaluating the use of high-dose IVC in cancer support. Based on data from these clinical studies, IVC used concurrently with oxidative therapies, such as chemotherapy and radiotherapy, seems to produce the greatest likelihood for improvements in quality of life and additive anti-tumour effects compared with IVC as monotherapy or with non-oxidative therapies. IVC has shown promise in improving quality of life in patients with breast cancer and advanced pancreatic and ovarian cancers. Limited evidence suggests survival and/or tumour response may be improved with the inclusion of IVC in patients with advanced pancreatic cancer, non-small cell lung cancer, and RAS-mutated colorectal cancer. IVC does not offer curative potential, and further research is needed to explore its effectiveness relevant to mortality outcomes. Practical guidance including assessment, monitoring, dosing, safety, and communication with other healthcare providers is discussed.</p> <p>DOI link: <a href="https://doi.org/10.54434/candj.149" target="_blank"> https://doi.org/10.54434/candj.149</a></p> <p> </p> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-author--research-abstract.html.twig * field--node--field-author.html.twig * field--node--research-abstract.html.twig * field--field-author.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-author field--type-text field--label-above"> <div class="field--label">Author</div> <div class="field--item"><p>Ellen Conte, ND, Erica Rizzolo, ND, Gillian Flower, ND, Mark Legacy, BSc, and Dugald Seely, ND, MSc</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-date--research-abstract.html.twig * field--node--field-date.html.twig * field--node--research-abstract.html.twig * field--field-date.html.twig * field--datetime.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-date field--type-datetime field--label-above"> <div class="field--label">Citedate</div> <div class="field--item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/modules/system/templates/time.html.twig' --> <time datetime="2024-03-21T12:00:00Z">2024-03-21</time> <!-- END OUTPUT from 'core/modules/system/templates/time.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-citation--research-abstract.html.twig * field--node--field-research-abs-citation.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-citation.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-citation field--type-text field--label-above"> <div class="field--label">Citation</div> <div class="field--item"><p>Conte E, Rizzolo E, Flower G, Legacy M, Seely, D. Intravenous vitamin C in cancer care: Evidence review and practical guidance for integrative oncology practitioners. CAND Journal. 2024;31(1):2-18. <a href="https://doi.org/10.54434/candj.149">https://doi.org/10.54434/candj.149</a></p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-publication--research-abstract.html.twig * field--node--field-research-abs-publication.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-publication.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-publication field--type-text field--label-above"> <div class="field--label">Publication</div> <div class="field--item"><p>CAND Journal</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-taxonomy--research-abstract.html.twig * field--node--field-taxonomy.html.twig * field--node--research-abstract.html.twig * field--field-taxonomy.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-taxonomy field--type-entity-reference field--label-above"> <div class="field--label">Taxonomy</div> <div class="field__items"> <div class="field--item"><a href="/research-abstracts/cancer" hreflang="en">Cancer</a></div> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> Wed, 27 Mar 2024 15:25:05 +0000 sana 4653 at https://ccnm.edu Integrative Oncology Care of Symptoms of Anxiety and Depression in Adults With Cancer: Society for Integrative Oncology–ASCO Guideline https://ccnm.edu/research-abstracts/integrative-oncology-care-symptoms-anxiety-and-depression-adults-cancer-society <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--research-abstract.html.twig x field--node--title.html.twig * field--node--research-abstract.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <span>Integrative Oncology Care of Symptoms of Anxiety and Depression in Adults With Cancer: Society for Integrative Oncology–ASCO Guideline</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--uid--research-abstract.html.twig x field--node--uid.html.twig * field--node--research-abstract.html.twig * field--uid.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--uid.html.twig' --> <span> <!-- THEME DEBUG --> <!-- THEME HOOK: 'username' --> <!-- BEGIN OUTPUT from 'core/modules/user/templates/username.html.twig' --> <span lang="" about="/user-profile/sana" typeof="schema:Person" property="schema:name" datatype="">sana</span> <!-- END OUTPUT from 'core/modules/user/templates/username.html.twig' --> </span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--uid.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--created--research-abstract.html.twig x field--node--created.html.twig * field--node--research-abstract.html.twig * field--created.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--created.html.twig' --> <span>Wed, 09/06/2023 - 17:23</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--created.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'links__node' --> <!-- FILE NAME SUGGESTIONS: * links--node.html.twig x links.html.twig --> <!-- BEGIN OUTPUT from 'themes/bootstrap/templates/system/links.html.twig' --> <!-- END OUTPUT from 'themes/bootstrap/templates/system/links.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--body--research-abstract.html.twig * field--node--body.html.twig * field--node--research-abstract.html.twig * field--body.html.twig * field--text-with-summary.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><h3>Purpose:</h3> <p>To provide evidence-based recommendations to health care providers on integrative approaches to managing anxiety and depression symptoms in adults living with cancer.</p> <h3>Methods:</h3> <p>The Society for Integrative Oncology and ASCO convened an expert panel of integrative oncology, medical oncology, radiation oncology, surgical oncology, palliative oncology, social sciences, mind-body medicine, nursing, methodology, and patient advocacy representatives. The literature search included systematic reviews, meta-analyses, and randomized controlled trials published from 1990 through 2023. Outcomes of interest included anxiety or depression symptoms as measured by validated psychometric tools, and adverse events. Expert panel members used this evidence and informal consensus with the Guidelines into Decision Support methodology to develop evidence-based guideline recommendations.</p> <h3>Results:</h3> <p>The literature search identified 110 relevant studies (30 systematic reviews and 80 randomized controlled trials) to inform the evidence base for this guideline.</p> <h3>Recommendations:</h3> <p>Recommendations were made for mindfulness-based interventions (MBIs), yoga, relaxation, music therapy, reflexology, and aromatherapy (using inhalation) for treating symptoms of anxiety during active treatment; and MBIs, yoga, acupuncture, tai chi and/or qigong, and reflexology for treating anxiety symptoms after cancer treatment. For depression symptoms, MBIs, yoga, music therapy, relaxation, and reflexology were recommended during treatment, and MBIs, yoga, and tai chi and/or qigong were recommended post-treatment.</p> <h3>Discussion:</h3> <p>Issues of patient-health care provider communication, health disparities, comorbid medical conditions, cost implications, guideline implementation, provider training and credentialing, and quality assurance of natural health products are discussed. While several approaches such as MBIs and yoga appear effective, limitations of the evidence base including assessment of risk of bias, nonstandardization of therapies, lack of diversity in study samples, and lack of active control conditions as well as future research directions are discussed.</p> <p>DOI link: <a href="https://ascopubs.org/doi/full/10.1200/JCO.23.00857" target="_blank">https://ascopubs.org/doi/full/10.1200/JCO.23.00857</a></p> <p> </p> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-author--research-abstract.html.twig * field--node--field-author.html.twig * field--node--research-abstract.html.twig * field--field-author.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-author field--type-text field--label-above"> <div class="field--label">Author</div> <div class="field--item"><p>L Carlson; N Ismaila; E Addington; G Asher; C Atreya; L Balneaves; J Bradt; N Fuller-Shavel; J Goodman; C Hoffman; A Huston; A Mehta; C Paller; K Richardson, D Seely; C Siwik; J Temel; Julia Rowland</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-date--research-abstract.html.twig * field--node--field-date.html.twig * field--node--research-abstract.html.twig * field--field-date.html.twig * field--datetime.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-date field--type-datetime field--label-above"> <div class="field--label">Citedate</div> <div class="field--item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/modules/system/templates/time.html.twig' --> <time datetime="2023-08-15T12:00:00Z">2023-08-15</time> <!-- END OUTPUT from 'core/modules/system/templates/time.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-citation--research-abstract.html.twig * field--node--field-research-abs-citation.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-citation.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-citation field--type-text field--label-above"> <div class="field--label">Citation</div> <div class="field--item"><p>DOI: 10.1200/JCO.23.00857 Journal of Clinical Oncology</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-publication--research-abstract.html.twig * field--node--field-research-abs-publication.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-publication.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-publication field--type-text field--label-above"> <div class="field--label">Publication</div> <div class="field--item"><p>Journal of Clinical Oncology</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-taxonomy--research-abstract.html.twig * field--node--field-taxonomy.html.twig * field--node--research-abstract.html.twig * field--field-taxonomy.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-taxonomy field--type-entity-reference field--label-above"> <div class="field--label">Taxonomy</div> <div class="field__items"> <div class="field--item"><a href="/research-abstracts/cancer" hreflang="en">Cancer</a></div> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> Wed, 06 Sep 2023 21:23:46 +0000 sana 4524 at https://ccnm.edu Mistletoe Extracts during the Oncological Perioperative Period: A Systematic Review and Meta-Analysis of Human Randomized Controlled Trials https://ccnm.edu/research-abstracts/mistletoe-extracts-during-oncological-perioperative-period-systematic-review-and <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--research-abstract.html.twig x field--node--title.html.twig * field--node--research-abstract.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <span>Mistletoe Extracts during the Oncological Perioperative Period: A Systematic Review and Meta-Analysis of Human Randomized Controlled Trials</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--uid--research-abstract.html.twig x field--node--uid.html.twig * field--node--research-abstract.html.twig * field--uid.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--uid.html.twig' --> <span> <!-- THEME DEBUG --> <!-- THEME HOOK: 'username' --> <!-- BEGIN OUTPUT from 'core/modules/user/templates/username.html.twig' --> <span lang="" about="/user-profile/sana" typeof="schema:Person" property="schema:name" datatype="">sana</span> <!-- END OUTPUT from 'core/modules/user/templates/username.html.twig' --> </span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--uid.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--created--research-abstract.html.twig x field--node--created.html.twig * field--node--research-abstract.html.twig * field--created.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--created.html.twig' --> <span>Wed, 09/06/2023 - 17:11</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--created.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'links__node' --> <!-- FILE NAME SUGGESTIONS: * links--node.html.twig x links.html.twig --> <!-- BEGIN OUTPUT from 'themes/bootstrap/templates/system/links.html.twig' --> <!-- END OUTPUT from 'themes/bootstrap/templates/system/links.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--body--research-abstract.html.twig * field--node--body.html.twig * field--node--research-abstract.html.twig * field--body.html.twig * field--text-with-summary.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><h3>Background:</h3> <p>We aim to evaluate the safety and efficacy of mistletoe extract (ME) use during the oncological perioperative period. Methods: Details registered a priori on PROSPERO (CRD42018086168). Results: Seven RCTs (comprising 663 participants in nine reports) and three nonrandomized studies were included. In five RCTs, ME was evaluated as adjunctive care and the control group had no additional intervention, whereas in two RCTs, ME was compared head-to-head against common cancer treatments (i.e., etoposide or bacillus Calmette-Guérin) with the intervention groups not receiving standard care. Meta-analyses found no evidence for a difference between ME and no added therapy for mortality and recurrence (RR, 95% CI: 1.00, 0.79–1.27; and 1.03, 0.79–1.33, respectively). Two RCTs reported beneficial effects of ME on immune cells, specifically natural killer cells, in colorectal cancer, and one RCT reported quality of life improvement. Two RCTs reported ME discontinuations due to adverse events and grade 3/4 toxicities. Nevertheless, no safety signals were detected from these 10 studies. Quality appraisal revealed a substantial risk of bias. Conclusions: Preliminary data are encouraging for mistletoe extracts, particularly in the context of colorectal cancer. However, the evidence is limited by the number of studies, an evaluation of different outcomes, and methodological limitations. Further high-quality research is warranted.</p> <p>DOI link: <a href="https://doi.org/10.3390/curroncol30090595" target="_blank">https://doi.org/10.3390/curroncol30090595</a></p> <p> </p> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-author--research-abstract.html.twig * field--node--field-author.html.twig * field--node--research-abstract.html.twig * field--field-author.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-author field--type-text field--label-above"> <div class="field--label">Author</div> <div class="field--item"><p>Cogo E, Elsayed M, Bhardwaj S, Cooley K, Aycho C, Liang V, Papadogianis P, Psihogios A, Seely D</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-date--research-abstract.html.twig * field--node--field-date.html.twig * field--node--research-abstract.html.twig * field--field-date.html.twig * field--datetime.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-date field--type-datetime field--label-above"> <div class="field--label">Citedate</div> <div class="field--item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/modules/system/templates/time.html.twig' --> <time datetime="2023-09-06T12:00:00Z">2023-09-06</time> <!-- END OUTPUT from 'core/modules/system/templates/time.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-citation--research-abstract.html.twig * field--node--field-research-abs-citation.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-citation.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-citation field--type-text field--label-above"> <div class="field--label">Citation</div> <div class="field--item"><p>Curr. Oncol. 2023, 30(9), 8196-8219; <a href="https://doi.org/10.3390/curroncol30090595">https://doi.org/10.3390/curroncol30090595</a></p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-publication--research-abstract.html.twig * field--node--field-research-abs-publication.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-publication.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-publication field--type-text field--label-above"> <div class="field--label">Publication</div> <div class="field--item"><p>Current Oncology</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-taxonomy--research-abstract.html.twig * field--node--field-taxonomy.html.twig * field--node--research-abstract.html.twig * field--field-taxonomy.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-taxonomy field--type-entity-reference field--label-above"> <div class="field--label">Taxonomy</div> <div class="field__items"> <div class="field--item"><a href="/research-abstracts/cancer" hreflang="en">Cancer</a></div> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> Wed, 06 Sep 2023 21:11:37 +0000 sana 4523 at https://ccnm.edu Vitamin C for the Treatment of Depression in Cancer Patients: A Literature Review https://ccnm.edu/research-abstracts/vitamin-c-treatment-depression-cancer-patients-literature-review <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--research-abstract.html.twig x field--node--title.html.twig * field--node--research-abstract.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <span>Vitamin C for the Treatment of Depression in Cancer Patients: A Literature Review</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--uid--research-abstract.html.twig x field--node--uid.html.twig * field--node--research-abstract.html.twig * field--uid.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--uid.html.twig' --> <span> <!-- THEME DEBUG --> <!-- THEME HOOK: 'username' --> <!-- BEGIN OUTPUT from 'core/modules/user/templates/username.html.twig' --> <span lang="" about="/user-profile/sana" typeof="schema:Person" property="schema:name" datatype="">sana</span> <!-- END OUTPUT from 'core/modules/user/templates/username.html.twig' --> </span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--uid.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--created--research-abstract.html.twig x field--node--created.html.twig * field--node--research-abstract.html.twig * field--created.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--created.html.twig' --> <span>Thu, 09/08/2022 - 17:54</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--created.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'links__node' --> <!-- FILE NAME SUGGESTIONS: * links--node.html.twig x links.html.twig --> <!-- BEGIN OUTPUT from 'themes/bootstrap/templates/system/links.html.twig' --> <!-- END OUTPUT from 'themes/bootstrap/templates/system/links.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--body--research-abstract.html.twig * field--node--body.html.twig * field--node--research-abstract.html.twig * field--body.html.twig * field--text-with-summary.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><h3>Introduction</h3> <p>One in two Canadians will be diagnosed with cancer in their lifetime and one in four will experience depression during their diagnosis. The cause of depression during cancer could be related to psychological, social, inflammatory, or immunological factors. Vitamin C can exert an effect on oxidative stress levels, adrenal function, and immune function and may have a role in the treatment of both cancer and depression. Vitamin C levels can affect neurotransmitter levels and its ability to increase quality of life in cancer patients, as well as relieve other cancer-related symptoms such as pain, has been documented.</p> <h3>Methods:</h3> <p>A systematic literature search was completed to identify all studies that assessed changes in depression symptom severity in patients receiving intravenous vitamin C treatment. The databases utilized include PubMed, Medline Complete, CINAHL Plus, Web of Science, Cochrane, and PMC. The inclusion criteria were: human participants with confirmed cancer of any type and stage, intravenous vitamin C treatment, with or without conventional treatment and with or without additional oral vitamin C dosing, and assessment of depression.</p> <h3>Results:</h3> <p>Out of 152 unique articles analyzed, four observational studies evaluate depression symptoms as part of an assessment of quality of life in cancer patients undergoing intravenous vitamin C treatment. All four studies reported improvement in mood.</p> <h3>Discussion:</h3> <p>The four included studies assessed the role of intravenous vitamin C in the treatment of depression in cancer patients. These studies confirmed previous research reporting improved quality of life and other cancer-related benefits (i.e. decreasing fatigue and pain). All four studies noted a decrease of depression in cancer patients which are summarized in Table 1. The included studies all evaluated safety and reported no significant adverse effects associated with the treatment.</p> <h3>Conclusion:</h3> <p>The current literature suggests that intravenous vitamin C could potentially have a beneficial effect on levels of depression in patients with cancer; however, more research is needed. Prospective clinical trials using validated assessment tools to capture changes in depression and control groups are needed to further study the potential role of this therapy in the treatment of depression in cancer patients.</p> <p>DOI Link: <a href="https://doi.org/10.26685/urncst.352" target="_blank">https://doi.org/10.26685/urncst.352</a></p> <p> </p> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-author--research-abstract.html.twig * field--node--field-author.html.twig * field--node--research-abstract.html.twig * field--field-author.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-author field--type-text field--label-above"> <div class="field--label">Author</div> <div class="field--item"><p>Jordan A. Kerner; Erica Eckstrand</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-date--research-abstract.html.twig * field--node--field-date.html.twig * field--node--research-abstract.html.twig * field--field-date.html.twig * field--datetime.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-date field--type-datetime field--label-above"> <div class="field--label">Citedate</div> <div class="field--item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/modules/system/templates/time.html.twig' --> <time datetime="2022-09-02T12:00:00Z">2022-09-02</time> <!-- END OUTPUT from 'core/modules/system/templates/time.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-publication--research-abstract.html.twig * field--node--field-research-abs-publication.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-publication.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-publication field--type-text field--label-above"> <div class="field--label">Publication</div> <div class="field--item"><p>URNCST Journal</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-taxonomy--research-abstract.html.twig * field--node--field-taxonomy.html.twig * field--node--research-abstract.html.twig * field--field-taxonomy.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-taxonomy field--type-entity-reference field--label-above"> <div class="field--label">Taxonomy</div> <div class="field__items"> <div class="field--item"><a href="/research-abstracts/cancer" hreflang="en">Cancer</a></div> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> Thu, 08 Sep 2022 21:54:24 +0000 sana 4196 at https://ccnm.edu Exploring the Effects of Yoga Therapy on Heart Rate Variability and Patient-Reported Outcomes After Cancer Treatment: A Study Protocol https://ccnm.edu/research-abstracts/exploring-effects-yoga-therapy-heart-rate-variability-and-patient-reported <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--research-abstract.html.twig x field--node--title.html.twig * field--node--research-abstract.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <span>Exploring the Effects of Yoga Therapy on Heart Rate Variability and Patient-Reported Outcomes After Cancer Treatment: A Study Protocol</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--uid--research-abstract.html.twig x field--node--uid.html.twig * field--node--research-abstract.html.twig * field--uid.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--uid.html.twig' --> <span> <!-- THEME DEBUG --> <!-- THEME HOOK: 'username' --> <!-- BEGIN OUTPUT from 'core/modules/user/templates/username.html.twig' --> <span lang="" about="/user-profile/sana" typeof="schema:Person" property="schema:name" datatype="">sana</span> <!-- END OUTPUT from 'core/modules/user/templates/username.html.twig' --> </span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--uid.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--created--research-abstract.html.twig x field--node--created.html.twig * field--node--research-abstract.html.twig * field--created.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--created.html.twig' --> <span>Mon, 05/16/2022 - 16:24</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--created.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'links__node' --> <!-- FILE NAME SUGGESTIONS: * links--node.html.twig x links.html.twig --> <!-- BEGIN OUTPUT from 'themes/bootstrap/templates/system/links.html.twig' --> <!-- END OUTPUT from 'themes/bootstrap/templates/system/links.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--body--research-abstract.html.twig * field--node--body.html.twig * field--node--research-abstract.html.twig * field--body.html.twig * field--text-with-summary.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item"><h3>Background:</h3> <p>Following cancer treatment, adults commonly report worsened patient-reported outcomes (PROs) such as anxiety, stress, depression, persistent and upsetting cognitive complaints, unrelenting fatigue, and reduced quality of life. Poorer PROs are associated with disrupted autonomic nervous system functioning as measured by heart rate variability (HRV), both of which have been associated with greater morbidity and mortality. Interventions to improve HRV and PROs among adults following cancer treatment are needed. Yoga therapy holds promise as an intervention to improve HRV and PROs. Therefore, we conducted a single-subject exploratory experimental study to investigate the effects of yoga therapy on HRV and specific PROs (ie, cancer-related fatigue, anxiety, cognitive function, depression, stress, quality of life) in adults treated for cancer. To reduce publication bias, improve reproducibility, and serve as a reference for forthcoming reporting of study results, we present the study protocol for this study herein.</p> <h3>Methods:</h3> <p>Participants were adults who completed cancer treatment that were recruited from the Ottawa Integrative Cancer Centre. Consenting and eligible participants received one 1:1 yoga therapy session (ie, 1 participant, 1 Yoga Therapist) and 6 weekly group-based yoga therapy sessions (ie, 2-3 participants, 1 Yoga Therapist). Participants completed assessments 7 times: 3 times prior to the program (ie, −6 weeks, −3 weeks, immediately prior to the 1:1 yoga therapy session), immediately following the 1:1 yoga therapy session, prior to the first group-based yoga therapy session, after the last group-based yoga therapy session, and at a 6-week follow-up. Hierarchical linear modeling will be used to test the average effects of the yoga therapy program across participants.</p> <h3>Discussion:</h3> <p>This study will explore several novel hypotheses, including whether yoga therapy can improve HRV and/or specific PROs among adults treated for cancer acutely (ie, during a 1:1 yoga therapy session) and/or through repeated exposure (ie, after completing 6 weeks of group-based yoga therapy). Although the findings will require confirmation or refutation in future trials, they may provide initial evidence that YT may benefit adults treated for cancer.</p> <p>DOI Link: <a href="https://dx.doi.org/10.1177/15347354221075576" target="_blank">https://dx.doi.org/10.1177/15347354221075576</a></p> <p> </p> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-author--research-abstract.html.twig * field--node--field-author.html.twig * field--node--research-abstract.html.twig * field--field-author.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-author field--type-text field--label-above"> <div class="field--label">Author</div> <div class="field--item"><p>Jennifer Brunet, PhD, Amanda Wurz, PhD, Julia Hussien, BSc, Anne Pitman, MSc, Ellen Conte, ND, Julie K. Ennis, PhD, Christophe L. Herry, PhD, Andrew J. E. Seely, MD, PhD, FRCSD, and Dugald Seely, ND</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-date--research-abstract.html.twig * field--node--field-date.html.twig * field--node--research-abstract.html.twig * field--field-date.html.twig * field--datetime.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-date field--type-datetime field--label-above"> <div class="field--label">Citedate</div> <div class="field--item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/modules/system/templates/time.html.twig' --> <time datetime="2022-01-07T12:00:00Z">2022-01-07</time> <!-- END OUTPUT from 'core/modules/system/templates/time.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-citation--research-abstract.html.twig * field--node--field-research-abs-citation.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-citation.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-citation field--type-text field--label-above"> <div class="field--label">Citation</div> <div class="field--item"><p>Brunet, J., Wurz, A., Hussien, J., Pitman, A., Conte, E., Ennis, J. K., Herry, C. L., Seely, A., &amp; Seely, D. (2022). Exploring the Effects of Yoga Therapy on Heart Rate Variability and Patient-Reported Outcomes After Cancer Treatment: A Study Protocol.</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-publication--research-abstract.html.twig * field--node--field-research-abs-publication.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-publication.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-publication field--type-text field--label-above"> <div class="field--label">Publication</div> <div class="field--item"><p>Integrative Cancer Therapies</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-taxonomy--research-abstract.html.twig * field--node--field-taxonomy.html.twig * field--node--research-abstract.html.twig * field--field-taxonomy.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-taxonomy field--type-entity-reference field--label-above"> <div class="field--label">Taxonomy</div> <div class="field__items"> <div class="field--item"><a href="/research-abstracts/cancer" hreflang="en">Cancer</a></div> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> Mon, 16 May 2022 20:24:32 +0000 sana 3787 at https://ccnm.edu Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis. https://ccnm.edu/research-abstracts/melatonin-treatment-cancer-systematic-review-randomized-controlled-trials-and <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--research-abstract.html.twig x field--node--title.html.twig * field--node--research-abstract.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <span>Melatonin in the treatment of cancer: a systematic review of randomized controlled trials and meta-analysis.</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--uid--research-abstract.html.twig x field--node--uid.html.twig * field--node--research-abstract.html.twig * field--uid.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--uid.html.twig' --> <span> <!-- THEME DEBUG --> <!-- THEME HOOK: 'username' --> <!-- BEGIN OUTPUT from 'core/modules/user/templates/username.html.twig' --> <span lang="" typeof="schema:Person" property="schema:name" datatype="">Anonymous (not verified)</span> <!-- END OUTPUT from 'core/modules/user/templates/username.html.twig' --> </span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--uid.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--created--research-abstract.html.twig x field--node--created.html.twig * field--node--research-abstract.html.twig * field--created.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--created.html.twig' --> <span>Tue, 08/24/2021 - 11:42</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--created.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'links__node' --> <!-- FILE NAME SUGGESTIONS: * links--node.html.twig x links.html.twig --> <!-- BEGIN OUTPUT from 'themes/bootstrap/templates/system/links.html.twig' --> <!-- END OUTPUT from 'themes/bootstrap/templates/system/links.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--body--research-abstract.html.twig * field--node--body.html.twig * field--node--research-abstract.html.twig * field--body.html.twig * field--text-with-summary.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item">Most observational studies show an association between melatonin and cancer in humans. We conducted a systematic review of randomized controlled trials (RCTs) of melatonin in solid tumor cancer patients and its effect on survival at 1 yr. With the aid of an information specialist, we searched 10 electronic databases from inception to October 2004. We included trials using melatonin as either sole treatment or as adjunct treatment. Pre-specified criteria guided our assessment of trial quality. We conducted a meta-analysis using a random effects model. We included 10 RCTs published between 1992 and 2003 and included 643 patients. All trials included solid tumor cancers. All trials were conducted at the same hospital network, and were unblinded. Melatonin reduced the risk of death at 1 yr (relative risk: 0.66, 95% confidence interval: 0.59-0.73, I2=0%, heterogeneity P</div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-author--research-abstract.html.twig * field--node--field-author.html.twig * field--node--research-abstract.html.twig * field--field-author.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-author field--type-text field--label-above"> <div class="field--label">Author</div> <div class="field--item"><p>Mills E, Wu P, Seely D, Guyatt G.</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-date--research-abstract.html.twig * field--node--field-date.html.twig * field--node--research-abstract.html.twig * field--field-date.html.twig * field--datetime.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-date field--type-datetime field--label-above"> <div class="field--label">Citedate</div> <div class="field--item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/modules/system/templates/time.html.twig' --> <time datetime="2005-01-01T12:00:00Z">2005-01-01</time> <!-- END OUTPUT from 'core/modules/system/templates/time.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-citation--research-abstract.html.twig * field--node--field-research-abs-citation.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-citation.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-citation field--type-text field--label-above"> <div class="field--label">Citation</div> <div class="field--item"><p>Journal of Pineal Research 2005;39(4):360-6.</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-affiliations--research-abstract.html.twig * field--node--field-research-abs-affiliations.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-affiliations.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-affiliations field--type-text field--label-above"> <div class="field--label">Affiliations</div> <div class="field--item"><p>McMaster University, Canadian College of Naturopathic Medicine</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-publication--research-abstract.html.twig * field--node--field-research-abs-publication.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-publication.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-publication field--type-text field--label-above"> <div class="field--label">Publication</div> <div class="field--item"><p><a href="http://onlinelibrary.wiley.com/doi/10.1111/j.1600-079X.2005.00258.x/abstract;jsessionid=C130F90830FEF3A9D559D3A9A30F5EC5.f03t03">http://onlinelibrary.wiley.com/doi/10.1111/j.1600-079X.2005.00258.x/abs…</a></p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-taxonomy--research-abstract.html.twig * field--node--field-taxonomy.html.twig * field--node--research-abstract.html.twig * field--field-taxonomy.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-taxonomy field--type-entity-reference field--label-above"> <div class="field--label">Taxonomy</div> <div class="field__items"> <div class="field--item"><a href="/research-abstracts/cancer" hreflang="en">Cancer</a></div> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> Tue, 24 Aug 2021 15:42:02 +0000 Anonymous 1364 at https://ccnm.edu The effects of green tea consumption on incidence of breast cancer and recurrence of breast cancer: a systematic review. https://ccnm.edu/research-abstracts/effects-green-tea-consumption-incidence-breast-cancer-and-recurrence-breast <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--research-abstract.html.twig x field--node--title.html.twig * field--node--research-abstract.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <span>The effects of green tea consumption on incidence of breast cancer and recurrence of breast cancer: a systematic review.</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--uid--research-abstract.html.twig x field--node--uid.html.twig * field--node--research-abstract.html.twig * field--uid.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--uid.html.twig' --> <span> <!-- THEME DEBUG --> <!-- THEME HOOK: 'username' --> <!-- BEGIN OUTPUT from 'core/modules/user/templates/username.html.twig' --> <span lang="" typeof="schema:Person" property="schema:name" datatype="">Anonymous (not verified)</span> <!-- END OUTPUT from 'core/modules/user/templates/username.html.twig' --> </span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--uid.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--created--research-abstract.html.twig x field--node--created.html.twig * field--node--research-abstract.html.twig * field--created.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--created.html.twig' --> <span>Tue, 08/24/2021 - 11:42</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--created.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'links__node' --> <!-- FILE NAME SUGGESTIONS: * links--node.html.twig x links.html.twig --> <!-- BEGIN OUTPUT from 'themes/bootstrap/templates/system/links.html.twig' --> <!-- END OUTPUT from 'themes/bootstrap/templates/system/links.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--body--research-abstract.html.twig * field--node--body.html.twig * field--node--research-abstract.html.twig * field--body.html.twig * field--text-with-summary.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item">BACKGROUND: Green tea is widely used by women for the prevention and treatment of breast cancer. The authors aimed to determine the efficacy of green tea ingestion on the risk of breast cancer development and the risk of breast cancer recurrence. METHODS: The authors conducted a systematic review and meta-analyses of observational studies from systematic searches of 8 electronic data sources and contact with authors. They included studies assessing breast cancer incidence and recurrence. RESULTS: Results: The pooled relative risk (RR) of developing breast cancer for the highest levels of green tea consumption in cohort studies was 0.89 (95% confidence interval [CI], 0.71-1.1; P= .28; I(2)= 0%), and in case control studies, the odds ratio was 0.44 (95% CI, 0.14-1.31; P= .14; I(2)= 47%). The pooled RR of cohort studies for breast cancer recurrence in all stages was 0.75 (95% CI, 0.47-1.19; P= .22; I(2)= 37%). A subgroup analysis of recurrence in stage I and II disease showed a pooled RR in cohort studies of 0.56 (95% CI, 0.38-0.83; P= .004; I2= 0%). Dose-response relationships were evident in only 3 of the 7 studies. CONCLUSION: To date, the epidemiological data indicates that consumption of 5 or more cups of green tea a day shows a non-statistically significant trend towards the prevention of breast cancer development. Evidence indicates that green tea consumption may possibly help prevent breast cancer recurrence in early stage (I and II) cancers. However, conclusions as to the potential therapeutic application of green tea are currently impossible to make due to the small number of studies conducted, the lack of any clinical trial evidence, the lack of a consistent dose-response relationship, and the potential for interaction with standard care. PMID: 15911927 </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-author--research-abstract.html.twig * field--node--field-author.html.twig * field--node--research-abstract.html.twig * field--field-author.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-author field--type-text field--label-above"> <div class="field--label">Author</div> <div class="field--item"><p>Seely D, Mills EJ, Wu P, Verma S, Guyatt GH.</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-date--research-abstract.html.twig * field--node--field-date.html.twig * field--node--research-abstract.html.twig * field--field-date.html.twig * field--datetime.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-date field--type-datetime field--label-above"> <div class="field--label">Citedate</div> <div class="field--item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/modules/system/templates/time.html.twig' --> <time datetime="2005-01-01T12:00:00Z">2005-01-01</time> <!-- END OUTPUT from 'core/modules/system/templates/time.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-citation--research-abstract.html.twig * field--node--field-research-abs-citation.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-citation.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-citation field--type-text field--label-above"> <div class="field--label">Citation</div> <div class="field--item"><p>Integr Cancer Ther. 2005;4(2):144-55.</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-affiliations--research-abstract.html.twig * field--node--field-research-abs-affiliations.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-affiliations.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-affiliations field--type-text field--label-above"> <div class="field--label">Affiliations</div> <div class="field--item"><p>Canadian College of Naturopathic Medicine</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-publication--research-abstract.html.twig * field--node--field-research-abs-publication.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-publication.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-publication field--type-text field--label-above"> <div class="field--label">Publication</div> <div class="field--item"><p><a href="http://ict.sagepub.com/content/4/2/144.long">http://ict.sagepub.com/content/4/2/144.long</a></p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-taxonomy--research-abstract.html.twig * field--node--field-taxonomy.html.twig * field--node--research-abstract.html.twig * field--field-taxonomy.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-taxonomy field--type-entity-reference field--label-above"> <div class="field--label">Taxonomy</div> <div class="field__items"> <div class="field--item"><a href="/research-abstracts/cancer" hreflang="en">Cancer</a></div> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> Tue, 24 Aug 2021 15:42:00 +0000 Anonymous 1352 at https://ccnm.edu An in vivo analysis of the herbal compound Essiac. https://ccnm.edu/research-abstracts/vivo-analysis-herbal-compound-essiac <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--research-abstract.html.twig x field--node--title.html.twig * field--node--research-abstract.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <span>An in vivo analysis of the herbal compound Essiac.</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--uid--research-abstract.html.twig x field--node--uid.html.twig * field--node--research-abstract.html.twig * field--uid.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--uid.html.twig' --> <span> <!-- THEME DEBUG --> <!-- THEME HOOK: 'username' --> <!-- BEGIN OUTPUT from 'core/modules/user/templates/username.html.twig' --> <span lang="" typeof="schema:Person" property="schema:name" datatype="">Anonymous (not verified)</span> <!-- END OUTPUT from 'core/modules/user/templates/username.html.twig' --> </span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--uid.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--created--research-abstract.html.twig x field--node--created.html.twig * field--node--research-abstract.html.twig * field--created.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--created.html.twig' --> <span>Tue, 08/24/2021 - 11:42</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--created.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'links__node' --> <!-- FILE NAME SUGGESTIONS: * links--node.html.twig x links.html.twig --> <!-- BEGIN OUTPUT from 'themes/bootstrap/templates/system/links.html.twig' --> <!-- END OUTPUT from 'themes/bootstrap/templates/system/links.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--body--research-abstract.html.twig * field--node--body.html.twig * field--node--research-abstract.html.twig * field--body.html.twig * field--text-with-summary.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item">BACKGROUND: Essiac is a herbal compound that has been in common use with cancer patients in North America for over 80 years. Despite its relatively widespread use, there are no peer-reviewed published reports of in vivo studies regarding the use of this compound.MATERIALS AND METHODS: Essiac was administered orally to test animals prior to all experiments. Standard assays to test protection from ethanol-induced gastric ulceration and carbon tetrachloride-induced hepatic injury were performed on Wistar rats. Assays of postglucose-load serum glucose and cellular and humoral immune modulation were conducted on ICR and BALB/C mice, respectively.RESULTS: Essiac demonstrated a modest gastric protective effect via reduction of ethanol-induced gastric ulceration. However, Essiac did not demonstrate significant hepatoprotective, hypoglycemic or immunomodulatory properties.CONCLUSION: Essiac, administered in established in vivo experimental models, did not significantly demonstrate its purported physiological modifying effects. PMID: 16886634 </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-author--research-abstract.html.twig * field--node--field-author.html.twig * field--node--research-abstract.html.twig * field--field-author.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-author field--type-text field--label-above"> <div class="field--label">Author</div> <div class="field--item"><p>Leonard BJ, Kennedy DA, Cheng FC, Chang KK, Seely D, Mills E.</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-date--research-abstract.html.twig * field--node--field-date.html.twig * field--node--research-abstract.html.twig * field--field-date.html.twig * field--datetime.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-date field--type-datetime field--label-above"> <div class="field--label">Citedate</div> <div class="field--item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/modules/system/templates/time.html.twig' --> <time datetime="2006-01-01T12:00:00Z">2006-01-01</time> <!-- END OUTPUT from 'core/modules/system/templates/time.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-citation--research-abstract.html.twig * field--node--field-research-abs-citation.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-citation.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-citation field--type-text field--label-above"> <div class="field--label">Citation</div> <div class="field--item"><p>Anticancer Research, 2006; 26(4B):3057-63.</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-affiliations--research-abstract.html.twig * field--node--field-research-abs-affiliations.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-affiliations.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-affiliations field--type-text field--label-above"> <div class="field--label">Affiliations</div> <div class="field--item"><p>University of Toronto, Canadian College of Naturopathic Medicine</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-taxonomy--research-abstract.html.twig * field--node--field-taxonomy.html.twig * field--node--research-abstract.html.twig * field--field-taxonomy.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-taxonomy field--type-entity-reference field--label-above"> <div class="field--label">Taxonomy</div> <div class="field__items"> <div class="field--item"><a href="/research-abstracts/cancer" hreflang="en">Cancer</a></div> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> Tue, 24 Aug 2021 15:42:00 +0000 Anonymous 1351 at https://ccnm.edu Metronomic dosing of chemotherapy: applications in pediatric oncology. https://ccnm.edu/research-abstracts/metronomic-dosing-chemotherapy-applications-pediatric-oncology <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--research-abstract.html.twig x field--node--title.html.twig * field--node--research-abstract.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <span>Metronomic dosing of chemotherapy: applications in pediatric oncology.</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--uid--research-abstract.html.twig x field--node--uid.html.twig * field--node--research-abstract.html.twig * field--uid.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--uid.html.twig' --> <span> <!-- THEME DEBUG --> <!-- THEME HOOK: 'username' --> <!-- BEGIN OUTPUT from 'core/modules/user/templates/username.html.twig' --> <span lang="" typeof="schema:Person" property="schema:name" datatype="">Anonymous (not verified)</span> <!-- END OUTPUT from 'core/modules/user/templates/username.html.twig' --> </span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--uid.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--created--research-abstract.html.twig x field--node--created.html.twig * field--node--research-abstract.html.twig * field--created.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--created.html.twig' --> <span>Tue, 08/24/2021 - 11:42</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--created.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'links__node' --> <!-- FILE NAME SUGGESTIONS: * links--node.html.twig x links.html.twig --> <!-- BEGIN OUTPUT from 'themes/bootstrap/templates/system/links.html.twig' --> <!-- END OUTPUT from 'themes/bootstrap/templates/system/links.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--body--research-abstract.html.twig * field--node--body.html.twig * field--node--research-abstract.html.twig * field--body.html.twig * field--text-with-summary.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item">Pediatric cancer has a better outcome profile than adult cancers. However, refractory disease and the potential for long-term morbidity resulting from the use of conventional therapies necessitate the development of novel treatments for this population. Recent advances in oncology include the use of low dose metronomic (LDM) chemotherapy. The promise of this novel therapeutic approach includes reduced toxicity and the potential for efficacy predominantly through an antiangiogenic effect. The clinical benefit may be realized especially when combined with other antiangiogenic agents and/or conventional maximally tolerated doses of chemotherapy. In this article, we review the evidence for the use of LDM chemotherapy with a focus on pediatric cancer. Included are some of the possible risks attributable to this therapy in a pediatric setting and some of the hurdles to overcome in order to conduct good clinical research. Emphasis is placed on the development of proper surrogate markers to monitor antiangiogenic therapy in order to both optimize the dosing schedule for LDM chemotherapy and to provide a way of tracking therapeutic efficacy. PMID: 16777697 </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-author--research-abstract.html.twig * field--node--field-author.html.twig * field--node--research-abstract.html.twig * field--field-author.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-author field--type-text field--label-above"> <div class="field--label">Author</div> <div class="field--item"><p>Stempak D, Seely D, Baruchel S.</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-date--research-abstract.html.twig * field--node--field-date.html.twig * field--node--research-abstract.html.twig * field--field-date.html.twig * field--datetime.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-date field--type-datetime field--label-above"> <div class="field--label">Citedate</div> <div class="field--item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/modules/system/templates/time.html.twig' --> <time datetime="2006-01-01T12:00:00Z">2006-01-01</time> <!-- END OUTPUT from 'core/modules/system/templates/time.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-citation--research-abstract.html.twig * field--node--field-research-abs-citation.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-citation.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-citation field--type-text field--label-above"> <div class="field--label">Citation</div> <div class="field--item"><p>Cancer Invest. 2006;24(4):432-43.</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-affiliations--research-abstract.html.twig * field--node--field-research-abs-affiliations.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-affiliations.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-affiliations field--type-text field--label-above"> <div class="field--label">Affiliations</div> <div class="field--item"><p>Hospital for Sick Children</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-publication--research-abstract.html.twig * field--node--field-research-abs-publication.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-publication.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-publication field--type-text field--label-above"> <div class="field--label">Publication</div> <div class="field--item"><p><a href="http://informahealthcare.com/doi/abs/10.1080/07357900600705599">http://informahealthcare.com/doi/abs/10.1080/07357900600705599</a></p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-taxonomy--research-abstract.html.twig * field--node--field-taxonomy.html.twig * field--node--research-abstract.html.twig * field--field-taxonomy.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-taxonomy field--type-entity-reference field--label-above"> <div class="field--label">Taxonomy</div> <div class="field__items"> <div class="field--item"><a href="/research-abstracts/cancer" hreflang="en">Cancer</a></div> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> Tue, 24 Aug 2021 15:42:00 +0000 Anonymous 1350 at https://ccnm.edu Barriers to participation in clinical trials of cancer: a meta-analysis and systematic review of patient-reported factors. https://ccnm.edu/research-abstracts/barriers-participation-clinical-trials-cancer-meta-analysis-and-systematic <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--title--research-abstract.html.twig x field--node--title.html.twig * field--node--research-abstract.html.twig * field--title.html.twig * field--string.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <span>Barriers to participation in clinical trials of cancer: a meta-analysis and systematic review of patient-reported factors.</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--title.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--uid--research-abstract.html.twig x field--node--uid.html.twig * field--node--research-abstract.html.twig * field--uid.html.twig * field--entity-reference.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--uid.html.twig' --> <span> <!-- THEME DEBUG --> <!-- THEME HOOK: 'username' --> <!-- BEGIN OUTPUT from 'core/modules/user/templates/username.html.twig' --> <span lang="" typeof="schema:Person" property="schema:name" datatype="">Anonymous (not verified)</span> <!-- END OUTPUT from 'core/modules/user/templates/username.html.twig' --> </span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--uid.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--created--research-abstract.html.twig x field--node--created.html.twig * field--node--research-abstract.html.twig * field--created.html.twig * field.html.twig --> <!-- BEGIN OUTPUT from 'core/modules/node/templates/field--node--created.html.twig' --> <span>Tue, 08/24/2021 - 11:41</span> <!-- END OUTPUT from 'core/modules/node/templates/field--node--created.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'links__node' --> <!-- FILE NAME SUGGESTIONS: * links--node.html.twig x links.html.twig --> <!-- BEGIN OUTPUT from 'themes/bootstrap/templates/system/links.html.twig' --> <!-- END OUTPUT from 'themes/bootstrap/templates/system/links.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--body--research-abstract.html.twig * field--node--body.html.twig * field--node--research-abstract.html.twig * field--body.html.twig * field--text-with-summary.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-body field--type-text-with-summary field--label-hidden field--item">BACKGROUND: Enrolling participants onto clinical trials of cancer presents an important challenge. We aimed to identify the concerns of patients with cancer about, and the barriers to, participation in clinical trials.METHODS: We did a systematic review to assess studies of barriers to participation in experimental trials and randomized trials for validity and content. We estimated the frequency with which patients identified particular issues by pooling across studies that presented data for barriers to participation in clinical trials as proportions.FINDINGS: We analyzed 12 qualitative studies (n=722) and 21 quantitative studies (n=5452). Two qualitative studies inquired of patients who were currently enrolled onto clinical trials, and ten inquired of patients who were eligible for enrolment onto various clinical trials. Barriers to participation in clinical trials were protocol-related, patient-related, or physician-related. The most common reasons cited as barriers included: concerns with the trial setting; a dislike of randomization; general discomfort with the research process; complexity and stringency of the protocol; presence of a placebo or no-treatment group; potential side-effects; being unaware of trial opportunities; the idea that clinical trials are not appropriate for serious diseases; fear that trial involvement would have a negative effect on the relationship with their physician; and their physician's attitudes towards the trial. Meta-analysis confirmed the findings of our systematic review.INTERPRETATION: The identification of such barriers to the participation in clinical trials should help trialists to develop strategies that will keep to a maximum participation and cooperation in cancer trials, while informing and protecting prospective participants adequately. PMID: 16455478 </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-author--research-abstract.html.twig * field--node--field-author.html.twig * field--node--research-abstract.html.twig * field--field-author.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-author field--type-text field--label-above"> <div class="field--label">Author</div> <div class="field--item"><p>Mills EJ, Seely D, Rachlis B, Griffith L, Wu P, Wilson K, Ellis P, Wright JR.</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-date--research-abstract.html.twig * field--node--field-date.html.twig * field--node--research-abstract.html.twig * field--field-date.html.twig * field--datetime.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-date field--type-datetime field--label-above"> <div class="field--label">Citedate</div> <div class="field--item"> <!-- THEME DEBUG --> <!-- THEME HOOK: 'time' --> <!-- BEGIN OUTPUT from 'core/modules/system/templates/time.html.twig' --> <time datetime="2006-01-01T12:00:00Z">2006-01-01</time> <!-- END OUTPUT from 'core/modules/system/templates/time.html.twig' --> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-citation--research-abstract.html.twig * field--node--field-research-abs-citation.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-citation.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-citation field--type-text field--label-above"> <div class="field--label">Citation</div> <div class="field--item"><p>Lancet Oncology, 2006;7(2):141-8.</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-research-abs-affiliations--research-abstract.html.twig * field--node--field-research-abs-affiliations.html.twig * field--node--research-abstract.html.twig * field--field-research-abs-affiliations.html.twig * field--text.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-research-abs-affiliations field--type-text field--label-above"> <div class="field--label">Affiliations</div> <div class="field--item"><p>McMaster University, Canadian College of Naturopathic Medicine</p> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> <!-- THEME DEBUG --> <!-- THEME HOOK: 'field' --> <!-- FILE NAME SUGGESTIONS: * field--node--field-taxonomy--research-abstract.html.twig * field--node--field-taxonomy.html.twig * field--node--research-abstract.html.twig * field--field-taxonomy.html.twig * field--entity-reference.html.twig x field.html.twig --> <!-- BEGIN OUTPUT from 'themes/pivot/templates/field.html.twig' --> <div class="field field--name-field-taxonomy field--type-entity-reference field--label-above"> <div class="field--label">Taxonomy</div> <div class="field__items"> <div class="field--item"><a href="/research-abstracts/cancer" hreflang="en">Cancer</a></div> </div> </div> <!-- END OUTPUT from 'themes/pivot/templates/field.html.twig' --> Tue, 24 Aug 2021 15:41:59 +0000 Anonymous 1339 at https://ccnm.edu