Flax and breast cancer: a systematic review

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BACKGROUND: Flax is a food and dietary supplement commonly used for menopausal symptoms. Flax is known for its lignan, alpha-linolenic acid, and fiber content, components that may possess phytogestrogenic, anti-inflammatory, and hormone modulating effects, respectively. We conducted a systematic review of flax for efficacy in improving menopausal symptoms in women living with breast cancer and for potential impact on risk of breast cancer incidence or recurrence. METHODS: We searched MEDLINE, Embase, the Cochrane Library, and AMED from inception to January 2013 for human interventional or observational data pertaining to flax and breast cancer. RESULTS: Of 1892 records, we included a total of 10 studies: 2 randomized controlled trials, 2 uncontrolled trials, 1 biomarker study, and 5 observational studies. Nonsignificant (NS) decreases in hot flash symptomatology were seen with flax ingestion (7.5 g/d). Flax (25 g/d) increased tumor apoptotic index (P
Title of abstract: 
Flax and breast cancer: a systematic review
Author: 
Flower G, Fritz H, Balneaves LG, Verma S, Skidmore B, Fernandes R, Kennedy DA, Cooley K, Wong R, Sagar S, Fergusson D, Seely D
Affiliations: 
CCNM, University of British Columbia, CAMEO Program, McMaster University, Ottawa Hospital Research Institute, Ottawa Integrative Cancer Centre
Citedate: 
Monday, December 31, 2012 - 19:00
Citation: 
Integr Cancer Ther. 2013 Sep 8;13(3):181-192.
Taxonomy: 
 

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