Effectiveness of smoking cessation therapies: a systematic review & meta-analysis.

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BACKGROUND: Smoking remains the leading preventable cause of premature deaths. Several pharmacological interventions now exist to aid smokers in cessation. These include Nicotine Replacement Therapy [NRT], bupropion, and varenicline. We aimed to assess their relative efficacy in smoking cessation by conducting a systematic review and meta-analysis. METHODS: We searched 10 electronic medical databases (inception to Sept. 2006) and bibliographies of published reviews. We selected randomized controlled trials [RCTs] evaluating interventions for smoking cessation at 1 year, through chemical confirmation. Our primary endpoint was smoking cessation at 1 year. Secondary endpoints included short-term smoking cessation (approximately 3 months) and adverse events. We conducted random-effects meta-analysis and meta-regression. We compared treatment effects across interventions using head-to-head trials and when these did not exist, we calculated indirect comparisons. RESULTS: We identified 70 trials of NRT versus control at 1 year, Odds Ratio [OR] 1.71, 95% Confidence Interval [CI], 1.55-1.88, P =
Title of abstract: 
Effectiveness of smoking cessation therapies: a systematic review and meta-analysis.
Author: 
Wu P, Wilson K, Dimoulas P, Mills EJ
Affiliations: 
McMaster University
Citedate: 
Saturday, December 31, 2005 - 19:00
Citation: 
BMC Public Health 2006;6:300.
Taxonomy: 
 

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